Articles Tagged With:
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Benefits of Nudging in Severe Aortic Stenosis
A single health system study of electronic provider notifications when severe aortic stenosis was discovered on echocardiography showed that referrals for aortic valve replacement significantly increased, especially in women and those > 80 years of age.
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Movement Disorder Emergencies: Serotonin Syndrome and Neuroleptic Malignant Syndrome
Serotonin syndrome and neuroleptic malignant syndrome are both potentially life-threatening conditions caused by medications. They present with altered mental status, autonomic dysfunction, and neuromuscular abnormalities. Despite overlapping features, they differ in etiology, pathophysiology, clinical presentation, and treatment.
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Can Vitamin D Supplementation Slow Cellular Aging?
In a large randomized, double-blind, placebo-controlled trial, vitamin D3 supplementation modestly but significantly slowed the rate of leukocyte telomere shortening over four years.
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Blood GFAP Measurements for Rapid Diagnosis of ICH
The early diagnosis of spontaneous intracerebral hemorrhage (ICH) is important to initiate rapid interventions, such as lowering blood pressure and reversing the effects of antithrombotic medications. Plasma assays of glial fibrillary acidic protein may become a useful tool for the prehospital diagnosis of ICH, but it needs further study before adoption in the clinical setting.
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Tolebrutinib May Slow Disability Progression in Patients with SPMS
A recent prospective study showed that tolebrutinib slows disability progression in patients with nonrelapsing secondary progressive multiple sclerosis (SPMS). There were some safety concerns, especially hepatotoxicity. A lack of demonstrated effect on some functional outcomes warrants careful consideration and continuing study.
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CSF α-Synuclein Seed Amplification Assays in Parkinsonian Syndromes
This large longitudinal study, which looked at cerebrospinal fluid α-synuclein seed amplification assays (SAAs) from three large cohorts, demonstrated efficacy in distinguishing between Parkinson’s disease and progressive supranuclear palsy, as well as predicting cognitive decline based on kinematic analysis of the SAA samples.
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Long-Term Peripheral Nerve Function Changes in People with Well-Controlled Type 2 Diabetes
The authors conducted a prospective observational study comparing the effect of early diagnosed, well-controlled type 2 diabetes on peripheral nerve function. Overall, they found similar rates of decline in nerve function in people with well-controlled diabetes compared to age- and sex-matched individuals with normal glucose tolerance. Given the similar decline in nerve function, the authors concluded that the course of diabetic sensorimotor neuropathy is influenced primarily by nerve function at the time of diagnosis and age-related physiological decline.
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Infectious Disease Updates
Do Gowns Help Prevent Transmission of Respiratory Viruses? How to Assess the ‘Wobble’ in Your IGRA?
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Fecal Microbiota Transplant as First-Line Therapy for Primary C. difficile Infection
In a randomized controlled trial conducted in Norway, fecal microbiota transplantation (FMT) was noninferior to vancomycin for the treatment of primary Clostridioides difficile infection, with 66.7% of patients in the FMT group achieving clinical cure without recurrence compared to 61.2% in the vancomycin group over 60 days of follow-up.
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In Vitro Activity of Newer Antibiotics Against CREs in the United States
The activity of newer beta-lactam/beta-lactamase combination antibiotics depends on the specific type of carbapenemase carried by carbapenem-resistant Enterobacterales.